Entwurf und Realisierung einer App zur Verwaltung von Taxonomien

Die Wartung von auf spezielle Themen zugeschnittene Taxonomien und Ontologien wird im Allgemeinen manuell durchgeführt. Dieser wiederkehrende Prozess wird oft von Experten der entsprechenden Domäne durchgeführt, benötigt viel Zeit und verursacht dadurch hohe Kosten. Um eine Kostensenkung zu erreichen, soll die benötigte Zeit gesenkt werden. Demzufolge soll im Rahmen dieser Arbeit ein Werkzeug entwickelt werden, das einen Experten bestmöglich bei der Wartung einer Taxonomie unterstützt. Hierzu wird ein Client-Server-System präsentiert, welches Taxonomien zentral vorhält und über einen Web-Service den Clients zur Verfügung stellt. Entwickelt werden sowohl der Server, als auch der Client. Serverseitig wird eine Applikation vorgestellt, die in einer relationalen Datenbank enthaltene Taxonomien und Funktionen zu deren Verwaltung über eine REST-Schnittstelle zur Verfügung stellt. Clientseitig wird eine auf Tablets ausgelegte Web-Applikation präsentiert, die in nahezu jeder Situation einen Zugriff auf eine Taxonomie erlaubt. Zusätzlich kann diese durch eine halbautomatische Erweiterung vervollständigt werden. Halbautomatisch bedeutet in diesem Kontext, dass Vorschläge für neue Synonyme für Konzepte außerhalb des Systems generiert und nach der Bewertung eines Experten in die Taxonomie übernommen werden können

Structural Evolution at the Northeast North German Basin Margin: From Initial Triassic Salt Movement to Late Cretaceous‐Cenozoic Remobilization

In this study, we investigate the regional tectonic impact on salt movement at the northeastern margin of the intracontinental North German Basin. We discuss the evolution of salt pillows in the Bay of Mecklenburg in the light of thick‐ and thin‐skinned tectonics, including gravity gliding, and differential loading using seismic imaging. Stratigraphic and structural interpretation of a 170 km long, multichannel seismic line, extending from the Bay of Mecklenburg to northeast of Rügen Island, incorporates well information of nearby onshore wells. This new high‐resolution seismic line completely images the stratigraphic and tectonic pattern of the subsurface, from the base of the Zechstein to the seafloor. Our analysis reveals that subsidence during Late Triassic to Early Cretaceous at the northeastern basin margin was associated with transtensional dextral strike slip movement within the Trans‐European Suture Zone. We reinterpret the Werre and Prerow Fault Zones west of Rügen Island as an inverted, thin‐skinned normal fault system associated with the formation of the Western Pomeranian Fault System. Salt movement in the Bay of Mecklenburg was initiated in the Late Triassic and lasted until the Early Jurassic. A second phase of salt pillow growth occurred during the Coniacian until Cenozoic and correlates with compression‐related regional basin inversion due to the onset of the Africa‐Iberia‐Europe convergence. Thin‐skinned extensional initialization of salt pillow growth and compressional salt remobilization explains salt pillow evolution in the Bay of Mecklenburg. Additionally, we discuss an impact of gravity gliding on salt pillow evolution induced by basin margin tilt.DFG, 61089689, SPP 1375: SAMPLE: South Atlantic Margin Processes and Links with onshore Evolutio

Prospective observational pilot study of young women undergoing initial breast cancer treatment and their biopsychosocial profile

Background: Breast cancer in young women can be a major challenge for those affected. To offer support, the establishment of a biopsychosocial profile may be beneficial. Methods: For this prospective observational pilot study, we collected data of 19 women with a mean age of 42.8 ± 5.4 years (30.0-49.0 year) before (T0) and after (T1) initial breast cancer treatment. The handgrip strength (HGS), 6-minute walk test (6MWT), and bioimpedance analysis for the detection of phase angle (PhA) and bioimpedance vector analysis (BIVA) were used. Assessments included the Hospital Anxiety and Depression Scale (HADS), Functional Assessment of Cancer Therapy-Breast (FACT-B), and Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F). Results: Women (age <50 years) with breast cancer showed impaired functional status (HGS, 6MWT, and PhA), abnormal physiologic findings (BIVA), decreased health-related quality of life (HRQoL), and cancer-related fatigue (CRF) after breast cancer diagnosis prior to the onset of cancer treatment with significant deterioration following cancer treatment. This was accompanied by a potentially higher risk of mortality and impaired function due to the prevalence of values below a critical threshold (PhA: T0 = 11%, T1 = 42%; HGS: T0 = 21%, T1 = 32%). In addition, there was evidence of anxiety (47%) and depression (32%) at T0. Conclusion: Routine assessment of biomarkers of physical function, mental health, HRQoL, and CRF may lead to individual risk stratification and multidisciplinary intervention in young patients with breast cancer, which could help to personalize and optimize survivorship care plans

Routine cancer treatments and their impact on physical function, symptoms of cancer-related fatigue, anxiety, and depression

Background and purpose. Breast cancer can be a major challenge for affected women. Knowledge of the physical function, symptoms of cancer-related fatigue, anxiety, and depression based on the cancer treatment may help to guide adequate support. Methods. For this prospective observational study, we collected data from seventy-nine women with a mean age 54.6 ± 9.5 years prior to the onset of breast cancer treatment (T0) and after (T1/T2). Handgrip strength test (HGS), six-minute walk test (6MWT), the phase angle (PhA), the hospital anxiety and depression scale (HADS), and functional assessment of chronic illness therapy-fatigue (FACIT-F) were used to collect data from four treatment subgroups SC, surgery + chemotherapy; SCR, surgery + chemotherapy + radiation therapy; SR, surgery + radiation therapy; and S, surgery. Results. A mixed ANOVA revealed a significant interaction between time and group for PhA, F = 8.55, p < 0.01; HGS, F = 3.59, p < 0.01; 6MWT, F = 4.47, p < 0.01; and FACIT-F, F = 2.77, p < 0.05 with most pronounced deterioration seen in group SCR (PhA 4.8°; HGS 27.5 kg, 6MWT 453.4 m, FACIT-F 33.8 points). HADS data displayed moderate anxiety and depression predominantly after treatment. Conclusion. Our study showed that the extent of change in physical function, symptoms of fatigue, anxiety, and depression depends on the treatment conditions. The potentially higher risk of impaired function due to the prevalence of values below a critical threshold requires early initiated multidisciplinary support

Расчетно-экспериментальное определение поля нейтронного излучения в защите из полиэтилена

Целью представленной работы является верификация кода PHITS для моделирования параметров нейтронного поля от закрытого 239Pu-Be источника нейтронов, расположенного в защите из полиэтилена. Верификация выполнена путем сравнения результатов расчета с экспериментальными данными. Верифицируемая лабораторная установка состоит из двух основных компонентов. Первым является 239Pu-Be источник нейтронов, а вторым – полиэтиленовая защита в форме четырехугольной призмы формы ("призма"). Разработанная расчетная модель для программы PHITS повторяет конфигурацию установки. Поток тепловых и быстрых нейтронов рассчитывался программой для точек, расположенных на оси облучательного канала "призмы", в диапазоне от 1 до30 см от ее боковой поверхности, с шагом равным 1 см. Эксперименты по измерению потоков нейтThe purpose of this work is verification of PHITS-code calculations for the simulation of neutron field parameters from the sealed 239Pu-Be source in polyethylene shielding. The verification was made by means of comparison of calculation results with the experimental data. The laboratory model consists of two main components. The first component is the 239Pu-Be source and the second component is the polyethylene prism. An identical PHITS model was generated to simulate the laboratory case. The neutron flux for both thermal and fast neutrons was calculated by PHITS code for every 1 cm in the range from 0 to 30 cm in front of the irradiation channel of the prism. Experiments have been performed in TPU laboratory. The neutron flux was measured in the laboratory for thermal neutrons at discre

Cancer treatment regimens and their impact on the patient-reported outcome measures health-related quality of life and perceived cognitive function

Background and purpose. Breast cancer can be a significant challenge for those affected. Knowledge of physical function, social-emotional challenges, and perceived cognitive function based on the cancer treatment regimens may help to inform adequate support. Methods. For this prospective observational pilot study, we collected data of seventy-nine women (mean age 54.6 ± 9.5 years) before (T0) and after (T1) initial breast cancer treatment. Functional Assessment of Cancer Therapy-Breast (FACT-B) and Functional Assessment of Cancer Therapy–Cognitive-Function (FACT-Cog) were used to collect data of four treatment subgroups: SCR = Surgery + Chemotherapy + Radiation Therapy; SC = Surgery + Chemotherapy; SR = Surgery + Radiation Therapy; S = Surgery. A mixed ANOVA and posthoc analysis (Tukey, Games-Howell) were used to detect interactions (group by time) and the main effect. A repeated-measures ANOVA displayed individual group differences (time). Results. Significant interaction showed more deterioration was experienced with SC and SCR than SR and S for FACT-B (p < 0.01) and FACT-Cog (p < 0.001). The longitudinal comparison between T0 and T1 indicated a significant group main effect on all subscales (p < 0.001) except for Emotional Well-Being. Significant reductions (p < 0.05) in FACT-B, (− 19%); FACT-Cog, (− 21%) with most pronounced effect in Physical Well-Being (− 30%), Functional Well-Being (− 20%), Breast Cancer Subscale (− 20%), Perceived Cognitive Impairments (− 18%) and Impact of Cognitive Impairments on Quality of Life (− 39%) were detected for SCR. Conclusion. Our study showed that the extent of change in health-related quality of life (HRQoL) and perceived cognitive function (PCF) depends on the treatment regimen. Multidisciplinary support initiated early in breast cancer therapy is needed, especially for women undergoing combined cancer treatment. Routine assessment of patient-reported outcomes (PROs) in oncology practice may increase the transparency of patients’ perceived circumstances, leading to personalized and optimized acute and survivorship care

Examining the generalizability of research findings from archival data

This initiative examined systematically the extent to which a large set of archival research findings generalizes across contexts. We repeated the key analyses for 29 original strategic management effects in the same context (direct reproduction) as well as in 52 novel time periods and geographies; 45% of the reproductions returned results matching the original reports together with 55% of tests in different spans of years and 40% of tests in novel geographies. Some original findings were associated with multiple new tests. Reproducibility was the best predictor of generalizability—for the findings that proved directly reproducible, 84% emerged in other available time periods and 57% emerged in other geographies. Overall, only limited empirical evidence emerged for context sensitivity. In a forecasting survey, independent scientists were able to anticipate which effects would find support in tests in new samples

A comprehensive model of seismic velocities for the Bay of Mecklenburg (Baltic Sea) at the North German Basin margin: implications for basin development

The geometry of sedimentary basins is normally described by the interpretation of seismic reflectors. In addition to that, rock properties of the sedimentary successions between these reflectors give further insight into the subsurface geology. Here, we present a model for the Bay of Mecklenburg, situated at the northeastern margin of the North German Basin. The model consists of eight layers; it covers seismic velocities of sediments from the Neogene down to the base of the Permian Zechstein. We use eight seismic profiles for model building and apply seismic migration velocity analysis in combination with pre-stack depth migration. The results are interval velocities down to a depth of 5000 m. A further aim of the study is to investigate the sensitivity of these indirectly deduced velocities in comparison to direct measurements within drill holes. The velocities from this study are in good agreement with earlier results from vertical seismic profiling at a nearby well. Cenozoic and Mesozoic strata within the Bay of Mecklenburg show clear depth-dependent velocity trends. A comparison of these trends with predicted compaction trends shows that burial anomalies within Lower Triassic units are significantly higher than in Upper Cretaceous units. This finding could be explained by a greater amount of erosion during Upper Jurassic/Lower Cretaceous times than during Cenozoic times. The Zechstein layer shows a decreasing interval velocity with increasing thickness. Our study demonstrates that seismic velocities deduced from surface-based measurements are of high value in areas with sparse drilling coverage.Bundesanstalt für Geowissenschaften und Rohstoffe (BGR) (4230)https://www.geo-seas.eu/search/welcome.php?query=1678&query_code=%7b558D29F1-65F5-4441-8CAF-8E15926546E9%7

A comprehensive model of seismic velocities for the Bay of Mecklenburg (Baltic Sea) at the North German Basin margin: implications for basin development

&lt;jats:title&gt;Abstract&lt;/jats:title&gt;&lt;jats:p&gt;The geometry of sedimentary basins is normally described by the interpretation of seismic reflectors. In addition to that, rock properties of the sedimentary successions between these reflectors give further insight into the subsurface geology. Here, we present a model for the Bay of Mecklenburg, situated at the northeastern margin of the North German Basin. The model consists of eight layers; it covers seismic velocities of sediments from the Neogene down to the base of the Permian Zechstein. We use eight seismic profiles for model building and apply seismic migration velocity analysis in combination with pre-stack depth migration. The results are interval velocities down to a depth of 5000 m. A further aim of the study is to investigate the sensitivity of these indirectly deduced velocities in comparison to direct measurements within drill holes. The velocities from this study are in good agreement with earlier results from vertical seismic profiling at a nearby well. Cenozoic and Mesozoic strata within the Bay of Mecklenburg show clear depth-dependent velocity trends. A comparison of these trends with predicted compaction trends shows that burial anomalies within Lower Triassic units are significantly higher than in Upper Cretaceous units. This finding could be explained by a greater amount of erosion during Upper Jurassic/Lower Cretaceous times than during Cenozoic times. The Zechstein layer shows a decreasing interval velocity with increasing thickness. Our study demonstrates that seismic velocities deduced from surface-based measurements are of high value in areas with sparse drilling coverage.&lt;/jats:p&gt